Our publications

2025

• Magdalena Lebiedzinska-Arciszewska*, Barbara Pakula, Massimo Bonora, Sonia Missiroli, Yaiza Potes, Patrycja Jakubek-Olszewska, Ines C. M. Simoes, Paolo Pinton and Mariusz R. Wieckowski "Distribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria—Associated Membranes Fractions in Normal and Oxidative Stress Conditions" International Journal of Molecular Sciences, 2025, accepted in press

• Lebiedzinska-Arciszewska M, Suski J, Bonora M, Pakula B, Pinton P, Duszynski J, Jakubek-Olszewska P#, Wieckowski MR#. "The Relation Between Mitochondrial Membrane Potential and Reactive Oxygen Species Formation" Methods Mol Biol. 2025;2878:133-162.

2024

• Wydrych A, Pakuła B, Jakubek-Olszewska P, Janikiewicz J, Dobosz AM, Cudna A, Rydzewski M, Pierzynowska K, Gaffke L, Cyske Z, Rintz E, Kurkowska-Jastrzębska I, Cwyl M, Pinton P, Węgrzyn G, Koopman WJH, Dobrzyń A, Skowrońska M, Lebiedzińska-Arciszewska M, Wieckowski MR. "Metabolic alterations in fibroblasts of patients presenting with the MPAN subtype of neurodegeneration with brain iron accumulation (NBIA)." BBA Mol Basis Dis. 2024 Oct 15:167541. 

• Agata Wydrych; Barbara Pakuła; Justyna Janikiewicz; Aneta M. Dobosz; Patrycja Jakubek-Olszewska; Marta Skowrońska; Iwona Kurkowska-Jastrzębska; Maciej Cwyl; Mariola Popielarz; Paolo Pinton; Barbara Zavan; Agnieszka Dobrzyń; Magdalena Lebiedzińska-Arciszewska and Mariusz R. Wieckowski "Metabolic Impairments in Neurodegeneration with Brain Iron Accumulation" BBA - Bioenergetics, 2024. Oct 2;1866(1):149517. 

• van de Wal MAE, Doornbos C, Bibbe J, Homberg JR, van Karnebeek C, Huynen MA, Keijer J, van Schothorst EM, 't Hoen PAC, Janssen MCH, Adjobo-Hermans MJW, Wieckowski MR, Koopman WJH. "Ndufs4 knockout mice with isolated complex I deficiency engage a futile adaptive brain response." Biochim Biophys Acta Proteins Proteom. 2024 Oct 10:141055.

• Monika Prill, Vilma A Sardão, Mateusz Sobczak, Dominika Nowis, Jedrzej Szymanski and Mariusz R. Wieckowski "p66Shc protein – oxidative stress sensor or redox enzyme, its potential role in mitochondrial metabolism of human breast cancer" Cancers, 2024. Sep 28;16(19):3324.

• Martina Trentini, Ugo D’Amora, Alfredo Ronca, Luca Lovatti, Jose’ Luis Calvo Guirado, Danilo Licastro, Simeone Dal Monego, Lucia Gemma Delogu; Mariusz R. Wieckowski, Shlomo Barak, Oleg Dolkart and Barbara Zavan "Unveiling the Bone Regeneration Revolution: Pulsed Electromagnetic Field Therapy Modulates Macrophage-Derived Exosomes to Attenuate Osteoclastogenesis" International Journal of Nanomedicine, 2024. Aug 24;19:8695-8707.

• Jakubek  P., Parchem K., Wieckowski M.R. and Bartoszek A. "The interplay between endogenous and foodborne prooxidants and antioxidants in shaping redox homeostasis" International Journal of Molecular Sciences, 2024. accepted, in press

• Sabinari I, Horakova O, Cajka T, Kleinova V, Wieckowski MR, Rossmeisl M. "Influence of Lipid Class Used for Omega-3 Fatty Acid Supplementation on Liver Fat Accumulation in MASLD" Physiol Res. 2024 Aug 31;73(Suppl 1):S295-S320.

• Białobrodzka E., Flis D.J., Akdogan B., Borkowska A, Wieckowski M.R., Antosiewicz J., Zischka H., Dzik K.P., Kaczor J.J. and  Ziolkowski W. "ALS disease and swim training affect copper metabolism in skeletal muscle in a mouse model of amyotrophic lateral sclerosis" Muscle and Nerve, 2024 Nov;70(5):1111-1118.

• Jakubek P#, Pakula B, Rossmeisl M, Pinton P, Rimessi A$ and Mariusz R. Wieckowski$,# Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies. Internal and Emergency Medicine, 2024. Aug;19(5):1473-1491.

• Aguilar K*, Jakubek P*, Zorzano A, Wieckowski MR. Primary mitochondrial diseases: The intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation. Eur J Clin Invest. 2024 Apr 21:e14217. doi: 10.1111/eci.14217. Epub ahead of print. PMID: 38644687.

• Patrycja Jakubek, Piotr Kalinowski, Agnieszka Karkucinska -Wieckowska, Aakruti Kaikini, Inês C. M. Simões, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Michał Grąt, Maciej Pronicki, Magdalena Lebiedzinska-Arciszewska, Marcin Krawczyk and Mariusz R. Wieckowski "Oxidative stress in metabolic dysfunction-associated steatotic liver disease (MASLD): how does the animal model resemble human disease?" FASEB Journal, 2024 Feb 15;38(3):e23466. doi: 10.1096/fj.202302447R.

• Francesca Marchetto, Sergio Santaeufemia, Magdalena Lebiedzińska-Arciszewska, Małgorzata Śliwińska, Magdalena Pich, Eliza Kurek, Aleksandra Naziębło, Marcin Strawski, Daniel Solymosi, Marek Szklarczyk, Ewa Bulska, Jędrzej Szymański, Małgorzata Wierzbicka, Yagut Allahverdiyeva-Rinne, Mariusz R. Więckowski and Joanna Kargul "Dynamic adaptation of the extremophilic red microalga Cyanidioschyzon merolae to high nickel stress" Plant Physiology and Biochemistry; 2024 - Feb;207:108365; doi: 10.1016/j.plaphy.2024.108365.

• Małgorzata Halon-Gołąbek* , Damian Jozef Flis*, Hans Zischka, Banu Akdogan, Mariusz Roman Wieckowski, Jedrzej Antosiewicz, Wiesław Ziolkowski "Amyotrophic lateral sclerosis associated disturbance of iron metabolism is blunted by swim training-role of AKT signaling pathway" BBA - Molecular Basis of Disease; 2024 Mar;1870(3):167014. doi: 10.1016/j.bbadis.2023.167014. IF = 6.2

• Marta Skowrońska#, Iwona Kurkowska-Jastrzębska, Agnieszka Cudna, Agnieszka Antos, Maciej Rydzewski, Justyna Janikiewicz, Aneta M. Dobosz, Agata Wydrych, Magdalena Lebiedzińska-Arciszewska, Barbara Pakuła, Patrycja Jakubek, Mariola Popielarz, Agnieszka Dobrzyń, Maciej Cwyl# and Mariusz R. Wieckowski# "Assessment of the degree of disability of the Polish NBIA MPAN population based on a patient survey" Current Neurology; 2024; 24 (1): 15–19

2023

• Jakubek P, Suliborska K, Kuczyńska M, Asaduzzaman M, Parchem K, Koss-Mikołajczyk I, Kusznierewicz B, Chrzanowski W, Namieśnik J, Bartoszek A. "The comparison of antioxidant properties and nutrigenomic redox-related activities of vitamin C, C-vitamers, and other common ascorbic acid derivatives." Free Radic Biol Med. 2023 Oct 20;209(Pt 2):239-251. doi: 10.1016/j.freeradbiomed.2023.10.400. Epub ahead of print. PMID: 37866756.  IF = 8.101

• Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G. "Platelet-derived lipids promote insulin secretion of pancreatic β cells." EMBO Mol Med. 2023 Sep 11;15(9):e16858. doi: 10.15252/emmm.202216858.  IF = 11.100

• Jakubek P, Rajić J, Kuczyńska M, Suliborska K, Heldt M, Dziedziul K, Vidaković M, Namieśnik J, Bartoszek A. "Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile - The Example of SRXN1 Gene" Antioxidants 2023, 12, 754. doi: 10.3390/antiox12030754. IF = 7.675

• Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. "PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment." Cell Death Differ. doi: 10.1038/s41418-022-01095-9. Epub ahead of print. IF = 12.067

• Perrone M, Patergnani S, Di Mambro T, Palumbo L, Wieckowski MR, Giorgi C, Pinton P. Calcium homeostasis in the control of mitophagy. Antioxid Redox Signal. doi: 10.1089/ars.2022.0122. Online ahead of print. IF = 7.468

• Ana I. Duarte*, Izabela Sadowska-Bartosz*, Agnieszka Karkucinska-Wieckowska*, Magdalena Lebiedzinska-Arciszewska*, Carlos M. Palmeira, Anabela P. Rolo, Yaschar Kabiri, Barbara Zavan, Paolo Pinton, Fernanda Borges, Hans Zischka#, John Griffith Jones#, Grzegorz Bartosz#, Paulo J. Oliveira#$, Mariusz R. Wieckowski#$ "A metabolic and mitochondrial angle on aging" (From Fundamental Biology to Societal Impact) Aging (2023) p.175-256 DOI: 10.1016/B978-0-12-823761-8.00005-7

2022

• Pedriali G,  Ramaccini D, Bouhamida E,  Wieckowski MR,  Giorgi C, Tremoli E and  Pinton P "Perspectives on mitochondrial relevance in Cardiac Ischemia/Reperfusion Injury" Front. Cell Dev. Biol. doi: 10.3389/fcell.2022.1082095 accepted in press. IF = 6.081

• Karimi S, Shahabi F, Mubarak SMH, Arjmandi H, Hashemi ZS, Pourzardosht N, Zakeri A, Mahboobi M, Jahangiri A, Rahbar MR, Khalili S. "Impact of SNPs, off-targets, and passive permeability on efficacy of BCL6 degrading drugs assigned by virtual screening and 3D-QSAR approach" Sci Rep. 2022 Dec 6;12(1):21091. doi: 10.1038/s41598-022-25587-3.  IF = 4.379

• Cieminski K, Flis DJ, Dzik KP, Kaczor JJ, Wieckowski MR, Antosiewicz J, Ziolkowski W. Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2022 Sep 29;23(19):11504. doi: 10.3390/ijms231911504.  IF = 6.208.

• Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, Simões RF, Karkucinska-Wieckowska A, Viegas I, Szymanska S, Dąbrowski M, Janikiewicz J, Cunha-Oliveira T, Dobrzyń A, Jones JG, Borges F, Wieckowski MR$, Oliveira PJ$ “Mitochondria-targeted anti-oxidant AntiOxCIN 4 improved liver steatosis in Western Diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and anti-oxidant defense systems” Redox Biology 2022; 55, 102400; ($-corresponding authors)  IF = 10.787

• Danese A, Patergnani S, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort R, Buser C, Ross-Cisneros FN, Sadun AA, Tacchetti C, Broccoli V, Giorgi C, Tiranti V, Carelli V and Pinton P "Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy" Cell Reports 2022; 40, 111124;   IF = 9.995

• Tarocco A, Morciano M, Perrone M, Cafolla C, Ferrè C, Vacca T, Pistocchi G, Meneghin F, Cocchi I, Lista G, Cetin I, Greco P, Garani G, Stella M, Natile M, Ancora G, Savarese I, Campi F, Bersani I, Dotta A, Tiberi E, Vento G, Chiodin E, Staffler A, Maranella E, Di Fabio S, Wieckowski MR, Giorgi C, Pinton P "Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic‐ischemic encephalopathy." Sci Rep. 2022; 12:7795.  IF = 4.379

• Ramaccini D, Pedriali G, Perrone M, Bouhamida E, Modesti L, Wieckowski MR, Giorgi C, Pinton P, Morciano G. "Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway" Biomedicines. 2022 Mar 21;10(3):726.   IF = 6.081

• Vezzani B, Carinci M, Previati M, Giacovazzi S, Della Sala M, Gafà R, Lanza G, Wieckowski MR, Pinton P, Giorgi C. "Epigenetic Regulation: A Link between Inflammation and Carcinogenesis" Cancers (Basel). 2022 Feb 26;14(5):1221. IF = 6.639

• Giampaolo Morciano, Gaia Pedriali, Elisa Mikus, Paolo Cimaglia, Simone Calvi, Rita Pavasini, Alberto Albertini, Roberto Ferrari, Mariusz R. Wieckowski, Carlotta Giorgi, Gianluca Campo and Paolo Pinton "Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore" European Journal of Clinical Investigation. 2022 Mar 15:e13764.;  IF = 4.686

• Esmaa Bouhamida, Giampaolo Morciano, Mariasole Perrone, Asrat Endrias Kahsay, Mario Della Sala, Mariusz R. Wieckowski, Francesco Fiorica, Paolo Pinton, Carlotta Giorgi and Simone Patergnani "The interplay of hypoxia signaling on mitochondrial dysfunction, and inflammation in cardiovascular diseases and cancer: from molecular mechanisms to therapeutic approaches" Biology 2022 Feb 12;11(2):300.   IF = 5.079

• Melissa van de Wal, Merel Adjobo-Hermans, Jaap Keijer, Tom Schirris, Judith Homberg, Mariusz R. Wieckowski, Sander Grefte, Evert M. van Schothorst, Clara van Karnebeek, Albert Quintana and Werner J.H. Koopman "Ndufs4 knockout mouse models of Leigh Syndrome: Pathophysiology and intervention." Brain 2022 Mar 29;145(1):45-63. doi: 10.1093/brain/awab426;   IF = 15.255

• Giampaolo Morciano, Alessandro Rimessi, Simone Patergnani, Veronica A M Vitto, Alberto Danese, Asrat Kahsay, Laura Palumbo, Massimo Bonora, Mariusz R Wieckowski, Carlotta Giorgi and Paolo Pinton  "Calcium dysregulation in heart diseases: targeting calcium channels to achieve a correct calcium homeostasis" Pharmacological Research 2022 Mar;177:106119.  IF = 7.658 

• A. Karkucinska-Wieckowska, I.C.M. Simoes, P. Kalinowski, M. Lebiedzinska-Arciszewska, K. Zieniewicz, P. Milkiewicz, M. Górska-Ponikowska, P. Pinton, A.N. Malik, M. Krawczyk, P.J. Oliveira, M.R. Wieckowski "Mitochondria, oxidative stress and Non-Alcoholic Fatty Liver Disease development: a complex relationship" European Journal of Clinical Investigation 2022 Mar;52(3):e13622. doi: 10.1111/eci.13622, IF = 6.686

2021

• Maciej K. Janik, Wiktor Smyk, Beata Kruk, Benedykt Szczepankiewicz, Barbara Górnicka, Magdalena Lebiedzińska-Arciszewska, Yaiza Potes, Inês C. M. Simões, Susanne N. Weber, Frank Lammert, Mariusz R. Więckowski, Piotr Milkiewicz, Marcin Krawczyk "MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis" Scientific Reports. 2021 Dec 23;11(1):24407. doi: 10.1038/s41598-021-03521-3;  IF = 5.133

• Agnieszka Zmyslowska; Miljan Kuljanin; Beata Malachowska; Marcin Stanczak; Dominika Michalek; Aneta Wlodarczyk; Dagmara Grot; Joanna Taha; Bartłomiej Pawlik; Magdalena Lebiedzińska-Arciszewska; Hanna Nieznanska; Mariusz R. Wieckowski; Piotr Rieske; Joseph D. Mancias; Maciej Borowiec; Wojciech Mlynarski; Wojciech Fendler "MULTIOMIC ANALYSIS ON HUMAN CELL MODEL OF WOLFRAM SYNDROME REVEALS CHANGES IN MITOCHONDRIAL MORPHOLOGY AND FUNCTION". Cell Communication and Signaling. 2021 Nov 20;19(1):116.  doi: 10.1186/s12964-021-00791-2;  IF = 5.712

• Cieminski K, Flis DJ, Dzik K, Kaczor JJ, Czyrko E, Halon-Golabek M, Wieckowski MR, Antosiewicz J, Ziolkowski W. Swim training affects Akt signaling and ameliorates loss of skeletal muscle mass in a mouse model of amyotrophic lateral sclerosis. Sci Rep. 2021 Oct 22;11(1):20899. IF = 4.379

• Simões ICM, Amorim R, Teixeira J, Karkucinska-Wieckowska A, Carvalho A, Pereira SP, Simões RF, Szymanska S, Dąbrowski M, Janikiewicz J, Dobrzyń A, Oliveira PJ, Potes Y, Wieckowski MR. "The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production." Int J Mol Sci. 2021 Jun 25;22(13):6848. IF = 5.923

• Giampaolo Morciano*, Natalia Naumova*, Piotr Koprowski, Sara Valente, Vilma A. Sardão, Yaiza Potes, Alessandro Rimessi, Mariusz R. Wieckowski$ and Paulo J. Oliveira$ “The Mitochondrial Permeability Transition: An Experimentally-driven Portrait in Movement” Biological Reviews 2021 Dec;96(6):2489-2521. doi: 10.1111/brv.12764. IF = 12.820; Wieckowski and Oliviera are both corresponding authors and share senior authorship.

• Simone Patergnani, Massimo Bonora,  Selene Ingusci,  Maurizio Previati, Saverio Marchi, Silvia Zucchini, Mariasole Perrone, Mariusz R. Wieckowski, Massimiliano Castellazzi, Maura Pugliatti, Carlotta Giorgi,  Michele Simonato, and  Paolo Pinton "Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis" PNAS June 15, 2021; 118 (24) e2020078118; IF = 11.205

• Lebiedzinska-Arciszewska M, Wojtczak L, Wieckowski MR. An Update on Isolation of Functional Mitochondria from Cells for Bioenergetics Studies. Methods Mol Biol. 2021;2310:79-89.

• Paulina Patalas-Krawczyk; Malinska Dominika; Jaroslaw Walczak; Monika Prill; Bernadeta Michalska; Karolina Drabik; Bjorn Titz; Yvan Eb-Levadoux; Thomas Schneider; Jedrzej Szymański; Julia Hoeng; Manuel Peitsch; Jerzy Duszyński; Joanna Szczepanowska; Carole Mathis; Mariusz R. Wieckowski “Effects of plant alkaloids on opening of the mitochondrial permeability transition pore” - Food and Chemical Toxicology 2021 Aug;154:112316, IF = 6.023

• Wieckowski MR, Pronicki M, Karkucinska-Wieckowska A. "Update on the Histoenzymatic Methods for Visualization of the Activity of Individual Mitochondrial Respiratory Chain Complexes in the Human Frozen Sections". Methods Mol Biol. 2021;2310:69-77.

• Alberto Danese, Sara Leo, Alessandro Rimessi, Mariusz R. Wieckowski, Francesco Fiorica, Carlotta Giorgi* and Paolo Pinton* “Cell death as a result of calcium signaling modulation: a cancer-centric prospective” BBA Molecular Cell Res. 2021 Jul;1868(8):119061,  IF = 4.739

• Ricardo Amorima, Inês Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereirad, Catarina Moraisa, Amália Juradoa, Mariusz R. Wieckowski, José Teixeira, Paulo J. Oliveira “Exploratory data analysis of cell and mitochondrial high-fat, high-sugar toxicity on human HepG2 cells” Nutrients 2021 May 19;13(5):1723, IF = 5.717

• M. Prill*, A. Karkucinska-Wieckowska*, M. Lebiedzinska-Arciszewska*, G. Morciano, A. Charzynska, P. Pinton, M. Dabrowski, M. Pronicki, W. Grajkowska$# and Wieckowski M. R.$# “Investigation of Ras and ShcA protein expression patterns in pediatric brain tumors” Journal of Clinical Medicine - 2021, 10(10), 2219., IF = 4.241

• Daniela Ramaccini, Vanessa Montoya-Uribe, Femke Femke Aan, Lorenzo Modesti, Yaiza Potes, Mariusz R. Wieckowski, Irena Krga, Marija Glibetic, Paolo Pinton, Carlotta Giorgi, Michelle Matter "Mitochondrial function and dysfunction in Cardiomyopathy" Frontiers in Cell and Developmental Biology (Cellular Biochemistry) 2021 Jan 12;8:624216. doi: 10.3389/fcell.2020.624216; IF = 6.684

• Alba Clara Sarti, Valentina Vultaggio-Poma, Simonetta Falzoni, Sonia Missiroli, Anna Lisa Giuliani, Paola Boldrini, Massimo Bonora, Francesco Faita, Nicole Di Lascio, Claudia Kusmic, Anna Solini, Salvatore Novello, Michele Morari, Marco Rossato, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton and Francesco Di Virgilio” The P2X7 receptor localizes to the mitochondria, modulates mitochondrial energy metabolism, and enhances physical performance" Function, Volume 2, Issue 2, 2021, zqab006, https://doi.org/10.1093/function/zqab006

• Simone Patergnani, Saverio Marchi, Benjamin Delprat and Mariusz R. Wieckowski “Editorial: Organelles Relationships and Interactions: A Cancer Perspective” Frontiers in Cell and Developmental Biology (Signaling); 9:678307. doi: 10.3389/fcell.2021.678307  IF = 6.684

• Giampaolo Morciano, Gaia Pedriali, Massimo Bonora, Rita Pavasini, Elisa Mikus, Simone Calvi, Matteo Bovolenta, Magdalena Lebiedzinska-Arciszewska, Mirko Pinotti, Alberto Albertini, Mariusz R. Wieckowski, Carlotta Giorgi, Roberto Ferrari, Lorenzo Galluzzi, Gianluca Campo, Paolo Pinton “New evidences on the pathological role of mitochondrial permeability transition pore in patients with STEMI”  Cell Reports, 2021; Apr 13;35(2):108983. doi: 10.1016/j.celrep.2021.108983.;  IF = 9.423