Curriculum vitae

In this summary, you will find an information about my recent research and an overview of my academic career after completing my PhD in Nencki Institute of experimental Biology in 1999. During 2002-2019, I have continued my academic career as postdoctoral researcher (2002-2004), assistant professor (1999-201), associate professor (2011-2016) and full professor (2016 till now). From the 1st of January 2020 I lead my own lab "Laboratory of Mitochondrial Biology and Metabolism" at Nencki Institute of Experimental Biology.

• • During my PhD research (1995-1999), I investigated protonophoric activity of long chain fatty acids under supervision of Prof. Lech Wojtczak. Our research proved that uncoupling of oxidative phosphorylation is not connected only with the uncoupling “flip-flop” mechanism of long chain fatty acids. It was then that we formulated a brave in those days hypothesis, that long chain fatty acids may be responsible for the opening of a mitochondrial megachannel.

  • During 2002-2004, I have worked as a research staff member at Ferrara University, and I have gained postdoctoral research experience and also supervised graduate students for their technical training. During this period, I have extended my research area on close interaction of endoplasmic reticulum (ER) with mitochondria, which optimized and streamlined calcium transport between these structures. As a member of Prof. Rizzuto’s team I significantly enriched my “research skills” which enabled progress of my studies concerning the structure and function of the megachannel. I tried prove that mitochondrial megachannel can be opened by calcium, which gets to mitochondria at the places of close contacts between endoplasmic reticulum and mitochondria. I was working on this project with dr Paolo Pinton (at present professor and the leader of Signal Transduction laboratory at Ferrara University), with whom I keep close scientific contacts up-to-present, and such collaboration is confirmed by many common publications.

  • I returned to Nencki Institute on 1^st October 2004 after completing my postdoctoral training abroad and with an intention to continue my earlier research on the structure of the megachannel and its regulation. A summary of those studies are three important for me publications: (Wieckowski et al., 2006; BBRC), (Szabadkai et al., 2006; J. Cell Biol.) and (Szabadkai et al., 2006; BBA). The results of all studies conducted in that period seemed to confirm the commonly accepted at that time model of a megachannel. It was five years later that we learnt how far we were from the truth. At the same time in collaboration with Prof. Rizzuto’s team I started at Nencki Institute my work on pro-oxidative role of an adaptor p66Shc protein which reveals itself in case of a cell response to the oxidative stress. This issue fascinated me during my postdoctoral training in Ferrara while we were studying an effect of activation of different protein kinase C isoforms (PKC) on cellular calcium homeostasis and the results of our research were published in (Pinton et al, 2004; J. Cell Biol.). Having on our disposal mice without p66Shc protein we wanted to check if that protein is really the key element of cellular response to the oxidative stress. We managed to do so in 2007 Science (Pinton et al., 2007; Science).

  • In 2008 I presented my habilitation thesis, which summarized my up-to-then research as well as knowledge about the mechanism of functioning and the structure of the mitochondrial megachannel. When my habilitation procedure was successfully finished I believed then that it was the final stage of my „adventure” with the megachannel and that I would devote all my efforts to p66Shc protein. However, later on I got back to that topic on multiplied occasions.

  • In 2007 I got a grant from the Ministry of Sciences and Higher Education (State Committee for Scientific Research) within which I intended to study mostly the effect of the p66Shc protein on mitochondrial metabolism. Together with my first PhD student Magdalena Lebiedzińska-Arciszewska we started intensive studies on the effect of p66Shc protein on mitochondrial metabolism and its involvement in the reactive oxygen species production. Thanks to development of special methods of cell subfractionation, we were able to show, that p66Shc does not translocate to the intermembrane space between outer and inner mitochondrial membranes, but rather interacts with the outer membrane from the cytosolic site. Interestingly, we observed the presence of this protein at the place of contacts between: plasma membrane, mitochondria and ER (PAM fraction - plasma membrane associated membranes) and mitochondria and endoplasmic reticulum (MAM fraction - mitochondria associated membranes) (Lebiedzinska et al., 2009; Arch Biochem Biophys).

  • Intrigued with this finding, I started a new trend in my studies dedicated to the scale of interactions between membranes of cellular organelles, which main goal was to learn their molecular structure and to explain their functions in physiology and pathology of cells. As a result of those studies we published many different works in this scope, out of which two published in Nature Protocols are worth special mentioning (Wieckowski et al., 2009; Nature Protocols) and (Suski at al., 2014; Nature Protocols). The experiments conducted by us in collaboration with collaboration with Prof. Pinton’s laboratory showed that at the places of contacts between mitochondria and endoplasmic reticulum also the PML protein is present where it plays an important role in cell death and inhibition of tumorogenesis and were finally published in 2010 in Science (Giorgi et al., 2010; Science). Being aware of great importance for a cell of places of direct interactions between organelles we are still following this research trend in the collaboration with international (prof. Paolo Pinton from University of Ferrara).

  • Cooperation started as early as 2006 with the Laboratory of Mitochondrial Medicine from the Pathology Department of The Children’s Memorial Health Institute has enabled us to change our approach in the studies of the p66Shc role in the cellular response to the oxidative stress. Studies conducted with the use of patient’s fibroblasts, harboring mutations in the nuclear or mitochondrial DNA responsible for mitochondrial dysfunction allowed us to prove that intracellular oxidative stress as a cause of mitochondrial dysfunction also takes a part in the activation of the pro-oxidative p66Shc pathway. We assumed that in the case of cellular response to the intracellular oxidative stress we can observe something like “vicious cycle” of reactive oxygen species production. Those studies were the subject of the common grant from the Ministry of Sciences and Higher Education with the Children’s Memorial Health Institute in years 2010-2013, where I was a principal investigator for the tasks conducted at the Nencki Institute of Experimental Biology.

  • Getting deeper and deeper into the topic of the oxidative stress accompanied by mitochondrial respiratory chain dysfunction, in years 2011-2014 in the range of “Harmonia” - international research project (where I was the principal investigator) from The National Science Centre I conducted studies on the TNFα-induced mitochondrial dysfunction in differentiating oligodendrocytes. Used by us in vitro model was supposed to imitate a situation in the pathogenesis of multiple sclerosis. This project was summarized in the PhD thesis of Jan Suski, my second in my scientific career PhD student. Most of these results were published in (Suski et al., 2012; Biochemical and Biophysical Research Communications) and (Bonora et al., 2014; Cell Death and Differentiation).

  • Year 2013 was for me extremely important especially because of one key discovery, which we managed to make in cooperation with two other scientific centers (with the group of prof. Pinton from University of Ferrara and the group of prof. Guido Kroemer from Paris University, Sorbon). Long-lasting discussions and new ideas to solve this problem made us have yet another look at this issue. There were two other groups sharing the same concept and competing with us, but fortunately we were the first to show that the mitochondrial megachannel is formed/created by a ring composed of the mitochondrial ATP synthase c-subunits (Bonora et al., 2013; Cell Cycle). In that same year after the publication of our work some new information started to come out, which confirmed our discovery. The issue turned out to be interesting enough that we are still studying it with use of the newest techniques of molecular biology and genetic engineering. The results of our recent findings I this research area have been published by us in (Bonora et al., 2015; Oncogene), (Morciano et al., 2015; J Mol Cell Cardiol), (Bonora et al., 2017; EMBO Rep.), (Bonora et al., 2016; Nature Protocols) and (Morciano et al., 2018; J Med Chem.).

  • The last six years I have been abroad several times for short visits to laboratories, both domestic and abroad, that my research team collaborates with. During my stays as well as during scientific conferences that I participated in, I have been able to meet many interesting people, who similarly to me, were fascinated with mitochondrial physiology and pathology. Those acquaintances on many occasions have transformed into joined scientific projects, which have resulted in numerous publications as well as in common grants, both domestic and foreign. As an example of such collaborative grants I can mention a) (2014-2016) grant from The National Science Centre, “The effect of swim training on life span, oxidative energy and oxidative stress metabolism in a mouse model of amyotrophic lateral sclerosis (ALS)” Role - Main Investigator; b) (2012-2014) grant from Foundation for Science and Technology, Lisbon, „Role of mitochondrial p66Shc in drug-induced mitochondrial toxicity memory„ Role - Main Investigator. During 2007-2019 I received eight research grants where I played a role as principal investigator.

  • Almost since 2007 in the Laboratory of Bioenergetics and Biomembranes at Nencki Institute governed by Prof. Jerzy Duszyński, I lead my own team continuing working on the molecular composition of mitochondrial megachannel and MAM and PAM physiology. As a result of these studies we published many different works in this scope e.g. (Giorgi et al., 2015; Proc Natl Acad Sci U S A), (Giorgi et al., 2015; Antioxid Redox Signal.), (Del Prete at al., 2017; J Alzheimers Dis.), (Danese et al., 2017; Biochim Biophys Acta), (Janikiewicz et al., Cell Death Dis.) and (Morciano et al., 2018; Neoplasia). My research was also focused on different aspects of intracellular oxidative stress (especially in the context of mitochondrial disorders) and resolving the issue how does mitochondrial dysfunction affect mitochondrial and cellular properties. The most important papers that are worth special mentioning are (Lebiedzinska et al., 2013; Int J Biochem Cell Biol), (Forkink et al., 2014; Biochim Biophys Acta.), (Distelmaier et al., 2015; Biochim Biophys Acta.), (Wojtala et al., 2017; Mitocondrion), (Jędrak et al., 2018; Metab Brain Dis.), and (Bonora et al., 2019; Nat Rev Cardiol.). Moreover, I was investigating the relations between mitochondrial energetic and oxidative stress in tumors as well as pharmacological toxicity to mitochondria (Rimessi et al. 2019; Semin Cell Dev Biol.) and (Malinska et al. 2018; Food Chem Toxicol.).

At present my research team in the Laboratory of Mitochondrial Biology and Metabolism at Nencki Institute consists of dr Aakruti Arun Kaikini (postdoc), dr Magdalena Lebiedzińska-Arciszewska (postdoc), Ines Simoes (PhD student), Monika Prill (PhD student), Arkadiusz Michałowski (PhD student), Solmaz Karimi (PhD student) and Agata Błażewicz (Laboratory administrator).

1. Education and degrees:

• 26.01.2016 – Professor (title), Nencki Institute of Experimental Biology; PAS.

• 26.09.2008 – Habilitation Nencki Institute of Experimental Biology PAS.

• 18.06.1999 - Ph.D. Laboratory of Bioenergetics, Biomembranes and Metabolic Regulations, Department of Cellular Biochemistry, Nencki Institute of Experimental Biology Polish Academy of Sciences. Supervisor: Prof. Lech Wojtczak „The role of long chain free fatty acids in the mitochondrial bioenergetics”

• 06.07.1995 - Master of Science at the Faculty of Biology, Department of Metabolic Regulations, Institute of Biochemistry, Warsaw University. Supervisor: Prof. Jadwiga Bryła „Regulation of synthesis of glycero-3-phosphatecholine in rabbit kidney medulla and in MDCK cells”

2. Academic and professional appointments

• 2016 - till now - professor - Nencki Institute of Experimental Biology, PAS

• 2011 - 2016 - associate professor - Nencki Institute of Experimental Biology, PAS

• 2004 - 2011 - assistant professor - Nencki Institute of Experimental Biology, PAS

• 2002 - 2004 - Post-doc, University of Ferrara, Italy

• 1999 - 2002 - assistant professor - Nencki Institute of Experimental Biology, PAS

• 1996 -1999 - senior research assistant - Nencki Institute of Experimental Biology, PAS

• 1995 -1996 - research assistant - Nencki Institute of Experimental Biology, PAS

• 1991 -1995 - technician - Warsaw University, Institute of Biochemistry, Department of Metabolic Regulation

1. Longer stays:

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy, collaborative research, Post-doctoral fellowship supported by EMBO Short-Term Fellowship (3 months, 2005)

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy, collaborative research, Post-doctoral fellowship supported by FEBS Long-Term Fellowship (01.10.2002 – 30.09.2004)

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy, collaborative research, Post-doctoral fellowship supported by Italian University Ministry (02.04.2002 – 31.09.2002)

2. Shorter stays:

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy; (3 weeks, 2014) - visiting scientist

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy, collaborative research supported by BIO-IMAGing in research INnovation and Education Project at the Nencki, supported by the EU FP7 Capacities Programme (3 weeks, 2013)

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy, collaborative research supported by BIO-IMAGing in research INnovation and Education Project at the Nencki, supported by the EU FP7 Capacities Programme (2 weeks, 2012)

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy; (2 weeks, 2008) - visiting scientist

• University of Konstanz, Faculty of Biology, Konstanz, Germany, collaborative research (1 month, 2000) - visiting scientist

• University of Konstanz, Faculty of Biology, Konstanz, Germany, collaborative research (2 months, 1999) - visiting scientist

• Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic, collaborative research, (1 month, 1997) - visiting scientist

• Institute of Biochemistry, Otto-von-Guericke University, Magdeburg, Germany; collaborative research, (1 week, 1996) - visiting scientist

3. Short research visits and invited lectures

• Center for Neurociences of Coimbra, University of Coimbra (2012, 2014, 2015, 2016, 2017, 2018, 2019,2021)

• University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy; (2007, 2008, 2009, 2010, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2021)

• Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München (2018, 2019)

• Italian Obesity Network, ADI Foundation, Pisa, Italy (2018)

• Radboud University Nijmegen, Netherlands (2013, 2014, 2017, 2019)

• Center for Neurociences of Coimbra, University of Coimbra (2013) Member of doctoral commission of Ana Filipa Roque Branco

• Center for Neurociences of Coimbra, University of Coimbra (2013) Member of doctoral commission of Catia Diogo

• The Physiology Department at University College London, (2008, 2009, 2010, 2012)

• Institut de Pharmacologie Moléculaire et Cellulaire CNRS-UMR 6097, Valbonne, France (2012) - seminar

• Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal 17.12.2010 - seminar

• University of Padova, Department of Biomedical Sciences, Italy; (2009)

• Fachbereich Medizin, JLU Giessen, Germany, (2007) - seminar

• Max-Delbrück-Center for Molecular Medicine, Berlin, Germany (2006) - seminar

• Medal of the 100th anniversary of the Nencki Institute, Director of the Nencki Institute, 2019

• Diploma for the achievements in popularization of science, Director of the Nencki Institute, 2019

• Gold-Cross, President of Poland, 2018

• The Polish Biochemical Society Bolesław Skarżyński Award for the best article published in a quarterly journal “Advances in Biochemistry” in year, 2010

• Silver-Cross, President of Poland, 2008

• Award for the research team from the Nencki Institute of Experimental Biology for the studies: „The role of mitochondria in the regulation of metabolism in the normal and pathological cells with particular reference to calcium homeostasis and apoptosis” Polish Academy of Sciences, 2007

• EMBO Short-Term Fellowship (3 months, 2005), Italy, University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy

• Grant to attend ELSO 2005, (European Life Scientist Organization) conference, Dresden, Germany, Foundation for Polish Science, 2005

• Grant from Bringing Research Advences in Neurobiology to Society “BRAINS” to attend the MIP conference „Mitochondrial Physiology 2005”, Schröcken, Austria

• Award „Cinema of the Cell 2004” – Bioclips Festival, organized by SBCF during ELSO 2004, Nicea (Mariusz R. Wieckowski, György Szabadkai, Anna M. Simoni, Diego De Stefani and Rosario Rizzuto; Cell death under the microscope: Cellular samurais)

• Award "Cinema of the Cell 2003” – Bioclips Festival, organized by SBCF during ELSO 2003, Drezno (Mariusz R. Wieckowski and Rosario Rizzuto Mitochondria and endoplasmic reticulum cooperation)

• Post-doctoral FEBS Long-Term Fellowship (01.10.2002 – 30.09.2004), University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy

• Post-doctoral fellowship supported by Italian University Ministry (02.04.2002 – 31.09.2002), University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Italy

• Youth FEBS grant to attend the FEBS Advanced Course on "Mitochondria in Cell Life and Death" (2001), Moscow, Russia

• Travel grant from The Batory Foundation (Warsaw) to attend the Advance Course on "Techniques in mitochondrial Physiology" (2001), Novato, USA

• Youth FEBS grant to attend the FEBS Advanced Course on" Expression and regulation of mitochondrial oxidative phosphorylation and disorders in human pathology” (2000), Martina Franca, Italy

• Molecular and Cellular Bilogy Network UNESCO, Short-Term Fellowship - 1 month (2000), University of Konstanz, Germany

• FEBS Short-Term Fellowship - 2 months (1999), University of Konstanz, Germany

• Fellowship for Young Scientists from the Foundation for Polish Science (1999)

• Award in Competition of Young Biochemists of the Polish Biochemical Society (1996)

• (2019-2022) Polish National Science Centre, Cracow [UMO-2018/29/B/NZ1/00589] „The role of oxidative stress in the pathogenesis of Non-Alcoholic Fatty Liver Disease” Role - Principal Investigator

• (2017-2021) European Commission, Brussels [Grant Agreement No. 734719 (mtFOIE GRAS)] „Non-invasive profiling of mitochondrial function in non-alcoholic fatty liver disease (NAFLD)” Role - Principal Investigator of the part performed at the Nencki Institute of Experimental Biology

• (2017-2021) European Commission, Brussels [GRANT AGREEMENT NUMBER — 722619 — Acronime “Foie Gras”] „Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease” Role - Principal Investigator of the part performed at the Nencki Institute of Experimental Biology

• (2015-2019) Polish National Science Centre, Cracow [UMO-2014/15/B/NZ1/00490] „The role of the mitochondrial dysfunction-related intracellular oxidative stress in pathogenesis of mitochondrial disorders” Role - Principal Investigator

• (2014-2016) 3-years research grant from The National Science Centre (NCN), Grant Nr. UMO-2013/09/B/NZ7/02538, “The effect of swim training on life span, oxidative energy and oxidative stress metabolism in a mouse model of amyotrophic lateral sclerosis (ALS)” Role - Main Investigator

• (2012-2015) 4-years research grant NCBiR Nr. PBS1/B8/1/2012 „From mitochondria to the innovative cosmetics with protective action” Role - Co-Investigator

• (2011-2014) 3-years research grant from The National Science Centre (NCN), Grant Nr NN303 47 05 38 “The role of mitochondria in the impairment of oligodendrocytes differentiation” Role - Principal Investigator

• (2011-2014) 4-years research grant Human Frontiers Scientific Program SPUB W100/HFSC/2011“ “The dark side of a bright molecule: Determinants of glycogen-induced cell dysfunction” Role - Co-Investigator

• (2011-2014) 4-years research Human Frontiers Scientific grant “The dark side of a bright molecule: Determinants of glycogen-induced cell dysfunction” Role - Co-Investigator

• (2011-2013) 3-years research grant FCT - Foundation for Science and Technology, FCT # PTDC/SAU-TOX/117912/2010, Portugal, “Role of mitochondrial p66Shc in drug-induced mitochondrial toxicity memory” Role - Principal Investigator of the part performed at the Nencki Institute of Experimental Biology

• (2010-2013) 3-years research grant from State Committee for Scientific Research - grant MNiSW Nr NN303 47 05 38 “ The role of tau protein and its phosphorylation in the regulation of prion-induced tubulin oligomeryzation” Role - Co-Investigator

• (2009-2012) 3-years research grant from State Committee for Scientific Research - grant MNiSW Nr. N N407 075 137 “Post-mortem investigations of mitochondrial disorders in fibroblasts” Role - Principal Investigator of the part performed at the Nencki Institute of Experimental Biology

• (2007-2010) 3-years research grant from State Committee for Scientific Research, COST/58/2007 “Effect of selenium on mitochondrial stress and their function” Role - Co-Investigator

• (2007-2010) 3-years research grant from State Committee for Scientific Research, Grant Nr N30109232/3407 “The role of p66Shc protein during oxidative stress” Role - Principal Investigator

• (2007-2010) 3-years research grant from State Committee for Scientific Research, Grant Nr N301012933 “The role of stearoyl-CoA desaturase in the pathogenesis of lipotoxic heart disease.” Role - Co-Investigator

• (2006-2009) 3-years research grant from State Committee for Scientific Research, Grant Nr N30108631/2742 “Identification of store operated calcium channel in the plasma membrane of Jurkat cells” Role - Co-Investigator

• (2006-2008) 3-years research grant from State Committee for Scientific Research, Grant Nr 2P04A 05729 “ Mild endoplasmic reticulum stress induced by Bcr-Abl oncogen as a mechanism activating antiapoptotic pathways in chronic leukemia” Role - Co-Investigator

• (2004-2006) 3-years research grant from Agency: AIRC “Intracellular calcium homeostasis, oncogenes and apoptosis: molecular determinants and trasduction pathways” Role - Co-Investigator

• (2003-2005) 3-years research grant from Agency: Cofin 2003 “Biopathology of the skeletal muscle fiber” Role - Co-Investigator

• (2002-2004) 3-years research grant from Agency: Telethon “Telethon center for cell imaging” Role - Co-Investigator

• (2002-2005) 3-years research grant from State Committee for Scientific Research, Grant Nr 3 P04A 041 23 “The role of mitochondria in the regulation of calcium metabolism in the normal and pathological cells. The role of mitochondria in the controlling of calcium channels in the plasma membrane. Role - Co-Investigator

• (1998-2002) 3-years research grant from State Committee for Scientific Research, Grant Nr. 6 P04A00516 “The role of mitochondria in apoptosis” Role - Co-Investigator

• (1995-1997) 3-years research grant from State Committee for Scientific Research, Grant Nr. 6 P04A05709 „Energetic of the animal cell: Homeostasis and regulation of the inorganic cations transport” Role - Co-Investigator

1. Supervision of postdosc:

• Dr Magdalena Lebiedzińska-Arciszewszka, Nencki Institute of Experimental Biology, Warsaw, Poland

• Dr Yaiza Potes Ochoa, Nencki Institute of Experimental Biology, Warsaw, Poland

• Dr Aakruti Arun Kaikini, Nencki Institute of Experimental Biology, Warsaw, Poland

2. Supervision of PhD students:

• Supervisor of Arkadiusz Michałowski PhD Thesis. Tentative Title: “Effect of melatonin on the mitochondrial permeability transition pore” at Nencki Institute of Experimental Biology, Warsaw, Poland; expected 2024/2025

• Supervisor of Solmaz Karimi PhD Thesis. Tentative Title: “The role of mitochondria-ER contact sites in the regulation of cancer cells metabolism” at Nencki Institute of Experimental Biology, Warsaw, Poland; expected 2024/2025

• Supervisor of Ines Simoes PhD Thesis. Tentative Title: “Effects of Western diet in the development and progression of Non-alcoholic fatty liver disease” at Nencki Institute of Experimental Biology, Warsaw, Poland; expected 2022

• Supervisor of Monika Prill PhD Thesis. Tentative Title: “The role of p66Shc protein in tumor cells” at Nencki Institute of Experimental Biology, Warsaw, Poland; expected 2022

• Second supervisor of Paulina Jędrak (Mozolewska) PhD Thesis “Changes in human cells mitochondria carrying the mutation in the IT15 gene” at University of Gdańsk, Gdańsk, Poland, 30 November 2018

• Supervisor of Aleksandra Wojtala PhD Thesis. Title: “Mitochondrial dysfunction caused by mitochondrial respiratory chain complex I defect in the Leigh disease models” at Nencki Institute of Experimental Biology, Warsaw, Poland 5^th December 2016

• Co-supervisor of the Federica Baldassari PhD Thesis. Title: “Involvement of transcription factor EB (TFEB) and c subunit of mitochondrial F1/Fo ATP synthase in cellular homeostasis“ Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara / Italy, 2015

• Co-supervisor of the Elena De Marchi PhD Thesis. Title: “Mitochondrial calcium uptake and release mechanisms as key regulators of cell life or death“ Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara / Italy, 28 March 2014

• Supervisor of Jan Suski PhD Thesis. Title: “Mitochondrial implications of tumor necrosis factor  mediated impairment of oligodendrocyte progenitor differentiation” at Nencki Institute of Experimental Biology, Warsaw, Poland 5^th November 2013

• Supervisor of Magdalena Lebiedzinska PhD Thesis. Title: “The role of p66Shc protein in the cellular response to the oxidative stress” at Nencki Institute of Experimental Biology, Warsaw, Poland, 21^st Jun 2011

• Co-supervisor of the Paola Maccarone MSc Thesis “Effectto della sovraespressione delle diverse isoforme del traslocatore degli Adenin Nucleotidi sull’ omeostasi intracellulare del calcio”, May 2002 at University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Ferrara, Italy

Moreover,

• Tutor of Ana Filipa Roque Branco part of PhD Thesis performed at the Nencki Institute of Experimental Biology PAS. Ttitle: “Impact of H9c2 Cardiomyoblast Differentiation on Isoproterenol Toxicity: Different Modulation of Signaling Pathways“ Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal, 13 Jun 2013

• Tutor of Catia Diogo part of PhD Thesis performed at the Nencki Institute of Experimental Biology PAS. Ttitle: “Oxidative stress, mitochondrial dysfunction and cellular pathology in experimental models of hyperglycaemia and high fat diet“ Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal, 12 July 2013

3. Supervision of visiting postdocs, PhD students and students during traineeship undergone in the Laboratory of Bioenergetics and Biomembranes:

• Dr. Angela Bononi (Postdoc at University of Hawaii Cancer Center) August - September 2017

• Angelica Ferro (Student at University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Ferrara, Italy) November 2016 and February 2017

• Paulina Jędrak (Mozolewska) (PhD student at at Gdańsk University) October – November 2015 and April – May 2016

• Federica Baldassari (PhD student at University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Ferrara, Italy) January - March 2014

• Catia Diogo (PhD student at Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal) September - December 2010; April - July 2011; and January - May 2012

• Dr. Massimo Bonora (Postdoc at University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Ferrara, Italy) April - May 2011

• Anna Branco (PhD student at Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal) September - December 2010

• Katarzyna Grad (Student - Department of Chemistry, Jagiellonian University) September 2013

• Fabio Ferri (Student at University of Ferrara, Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, Ferrara, Italy) July - September 2013

• Agnieszka Toma (PhD student - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Onclology Gliwice Branch) September - November 2012

• Jordi Jacas i Mateu (PhD student - Facultat de Medicina i Ciències de la Salut Universitat Internacional de Catalunya Josep Trueta, Barcelona) October - November 2012

1. Reviewer of the PhD thesis:

• Monika Pichla PhD Thesis. Title: "......." ; Rzeszów University, Poland 2021

• Katarzyna Niedźwiecka PhD Thesis. Title: “Drożdże jako organizm modelowy do badań dysfunkcji syntazy ATP w miopatiach i nowotworach” at the Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, 2018

• Alberto Danese PhD Thesis. Title: “Linking mitochondria to different human disorders: implication of mitophagy in LHON disease and characterization of the mitochondrial Ca²⁺ regulator MCUb in cancer progression” at Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy, 2017

• Claudia Morganti PhD Thesis. Title: “Regulation of cell death and differentiation: new roles for ATP synthase, PML and mitochondria metabolites” at Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy, 2017

• Agnieszka Kozieł PhD Thesis. Title: “Metabolizm tlenowy ludzkich komórek śródbłonka w warunkach fizjologicznych i patofizjologicznych” at Adam Mickiewicz University, Poznan, Poland, 2016

• Agnieszka Toma-Jonik PhD Thesis. Title: “Rola czynnika transkrypcyjnego HSF1 w progresji nowotworu i chemooporności komórek czerniaka” at Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice, Gliwice, Poland, 2015

• Angela Bononi PhD Thesis. Title: “From cell signalling to cell death: endoplasmic reticulum-mitochondria calcium transfer and its remodelling for cancer cell surviva” at Dept. of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy, 2017

• Angelika Muchowicz PhD Thesis. Title: “Próby zastosowania inhibitorów tioredoksyny w leczeniu nowotworów” at Medical University of Warsaw, Warsaw, Poland, 2012

• Hanna Gałgańska PhD Thesis. Title: “Zmiany stanu oksydacyjno-redukcyjnego cytoplazmy jako element komunikacji jądro komórkowe-mitochondria” at Adam Mickiewicz University, Poznan, Poland, 2010

• Anna Węglewska-Jurkiewicz PhD Thesis. Title: “Deplecje mitochondrialnego DNA w genetycznie uwarunkowanych chorobach człowieka” at Gdańsk University, Gdańsk, Poland, 2009

2. Reviewer of habilitation thesis:

• Dr Łukasz Opaliński Habilitation Thesis Title: “Potranslacyjne mechanizmy transportu i sortowania białek w komórkach eukariotycznych” at Faculty of Biotechnology, University of Wrocław, Wrocław, Poland, 2019

• Dr Kamil Brzóska Habilitation Thesis Title: “Sygnalizacja komórkowa związana z rozwojem reakcji zapalnej i apoptozą w odpowiedzi komórki na czynniki wywołujące stres oksydacyjny i uszkodzenia DNA” at Centre for Radiobiology and Biological Dosimetry, Warsaw, Poland, 2018

• Dr Małgorzata Wojtkowska Habilitation Thesis Title: “Sygnalizacja komórkowa związana z rozwojem reakcji zapalnej i apoptozą w odpowiedzi komórki na czynniki wywołujące stres oksydacyjny i uszkodzenia DNA” at Adam Mickiewicz University, Poznan, Poland, 2018

• Dr Małgorzata Słocińska Habilitation Thesis Title: “Identyfikacja i charakterystyka systemów rozpraszających energię w mitochondriach ciała tłuszczowego i mięśni karaczana Gromphadorhina coquereliana oraz chrząszcza Zophobas atratus” at Adam Mickiewicz University, Poznan, Poland, 2017

• Dr Rafał Dutkiewicz Habilitation Thesis Title: “Analiza strukturalno-funkcjonalna mitochondrialnych kompleksów białkowych zaangażowanych w biosyntezę centrów żelazo-siarkowych (Fe/S)” at Intercollegiate Faculty of Biotechnology UG&MUG, Gdańsk, Poland, 2016

3. Reviewer of professor applications:

• Dr hab. Przemysław Tylżanowski professor application. Medical University of Lublin, Lublin, Poland 2020

• Dr hab. Natalia Kurhaluk professor application. Institute of Biology and Earth Sciences Pomeranian University in Słupsk, Słupsk, Poland 2020

• Dr hab. Izabela Sadowska-Bartosz professor application. Jagiellonian University, Kraków, Poland, 2019

• Dr hab. Katarzyna Tońska professor application. Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, 2018

• Reviewer of grant proposals for European Commission; Marie Sklodowska Curie Action Individual Fellowships (MSCA-IF) Panel Experts 2018/2020/2021

• Grants Judging Committee in Czech Science Foundation 2015/2020/2021

• Reviewer of EARLY CAREER AWARD Regional Foundation for Biomedical Research, Milan, Italy 2020

• Reviewer of grants applications for AFM-TELETHON The Scientific Committee MOLECULAR & PHYSIOPATHOLOGICAL BASIS OF OTHER NM DISEASES. 2020/2021

• Reviewer of grant applications for AFM-TELETHON, Scientific Committee GENE AND/OR CELL THERAPY OF RARE DISORDERS 2016/2017/2018;

• Reviewer of grant proposals for the Polish National Agency for Academic Exchange; Program „Polskie Powroty” 2019

• Reviewer of grant proposals for the Polish National Agency for Academic Exchange; Program „Bekker” 2018

• Reviewer of grant proposals for Veni programme; The Netherlands Organisation for Health Research and Development 2018

• Reviewer of grant applications for Swiss National Science Foundation, 2018

• Reviewer of grant applications for Italian Ministry for Education, University and Research, 2017

• Member of the National Science Centre panel of experts (panel NZ1- Molecular and Structural Biology and Biochemistry), 2012/2013

• External expert (reviewer) of the National Science Centre panel NZ3 (Cellular and Developmental Biology), 2011/2012

• The member of grants committee (reviewer of applications) in the frame of „DrINNO 2 - building the social potential of top-class specialists in the Warmian-Mazurian province” project, 2010

• Reviewer of applications in the Homing Plus Program (2/2010) Foundation for Polish Science

• Reviewer of applications in the 2nd edition of „Regional Found of Doctoral Fellowships 2” (RFSD2) from the resources of European Social Fund, in the frame of the Integrated Regional Operational Programme, 2009

1. Lectures in scientific meetings:

• Mariusz R. Wieckowski “What can we foretell from the mitochondrial parameters” Second edition of MAD (Mitochondria, Ageing & Disease) retreat “Science Out of the Box” organized by Center for Innovative Biomedicine and Biotechnology (CIBB). 17-18 November 2021.

• Mariusz R. Wieckowski “What can we foretell from the plasma biomarkers - predicting Nonalcoholic Fatty Liver Disease” European Society for Clinical Investigation (ESCI) 55th Annual Scientific Meeting, Virtual Meeting / COVID19 Edition 2021, 9-11 June 2021.

• Mariusz R. Wieckowski „Mitochondria-Associated ER Membranes: A cancer perspective” 2nd FEBS Advanced Lecture Course on Oncometabolism-From Conceptual Knowledge to Clinical Applications", Luso, Portugal, 1 - 6 September 2019

• Mariusz R. Wieckowski „Changes in the OXPHOS proteome and alterations of mitochondrial parameters in fibroblasts of patients harboring defined mitochondrial disorders” XVII International Conference on Rare Diseases: Understanding Rare Diseases, Serock, Poland, 27 - 30 June 2019

• Mariusz R. Wieckowski „Alterations in the mitochondrial function and proteome in Non-Alcoholic Fatty Liver Disease” European Society for Clinical Investigation (ESCI) 53rd Annual Scientific Meeting, Coimbra, Portugal, May 22 - 24, 2019

• Mariusz R. Wieckowski „Oxidative stress in development of NAFLD” European Society for Clinical Investigation (ESCI) 53rd Annual Scientific Meeting, Coimbra, Portugal, May 22 - 24, 2019

• Mariusz R. Wieckowski „New advances in the mitochondrial permeability transition pore structure” European Society for Clinical Investigation (ESCI) 52nd Annual Scientific Meeting, Barcelon, Spain, May 30 - Jun 1st, 2018

• Mariusz R. Wieckowski „Mitochondrial dysfunction in Non-Alcoholic Fatty Liver Disease” 7th Mitochondrion, Wrocław, Poland, 18-19 October 2018

• Mariusz R. Wieckowski „p66Shc protein – a possible link between mitochondria, Mitochondria associated membranes and ROS in ageing and senescence” International Conference „Biomedical theories of aging”, Rzeszów, Poland, June 20 – 22, 2018,

• Mariusz R. Wieckowski „What can we foretell from the mitochondrial parameters, in other words, profiling of mitochondrial bioenergetic parameters and manifestation of the oxidative stress in fibroblasts of patients suffering from mitochondrial disease” XVI International Conference on Rare Diseases: Understanding Rare Diseases, Serock, Poland, 28 June – 1 July 2018

• Mariusz R. Wieckowski „Characterization of the mitochondrial bioenergetics, ROS and status of antioxidant defense system profiles in fibroblasts of patients showing mitochondrial abnormalities” European Society for Clinical Investigation (ESCI) 51st Annual Scientific Meeting, Genoa, Italy, 17 - 19 May, 2017

• Mariusz R. Wieckowski „Oxidative stress and mitochondrial abnormalities in skin fibroblasts derived from patients with the defects of the mitochondrial respiratory chain” European Society for Clinical Investigation (ESCI) 50th Annual Scientific Meeting, Paris, France, April 27 - 29, 2016

• Mariusz R. Wieckowski „The Role of Mitochondria in the TNFa-induced Impairment of Oligodendrocytes Differentiation” European Society for Clinical Investigation (ESCI) 49th Annual Scientific Meeting, Cluj-Napoca, Romania, May 27 - 30, 2015

• Mariusz R. Wieckowski „The mitochondrial permeability transition pore – myths and new facts - is the MPTP structure solved?” European Society for Clinical Investigation (ESCI) 48th Annual Scientific Meeting, Utrecht, The Netherlands, April 30 - May 3, 2014

• Mariusz R. Wieckowski „Mitochondrial parameters and ROS production can be used to differentiate mitochondrial defects in fibroblasts from patients with mitochondrial defects” 9th MiPconference - MiP2013: Comparative Mitochondrial Physiology, Obergurgl, Tyrol, Austria. September 23 – 27, 2013

• Mariusz R. Wieckowski „The mystery of mam fraction – the role of mitochondria associated membranes components in mitochondrial physiology and pathology” European Society for Clinical Investigation (ESCI) 47th Annual Scientific Meeting, Albufeira, Portugal, April 17-20, 2013

• Mariusz R. Wieckowski „Mitochondrial bioenergetic parameters, reactive oxygen species production and the status of antioxidant defense system can be used to differentiate mitochondrial defects studied in the fibroblasts from patients with various mitochondrial disorders” Polish Biochemical Society Meeting, Toruń, Poland, September 2nd-5th 2013

• Mariusz R. Wieckowski „ Aging and mitochondrial dysfunctions - the role of p66Shc lifespan-regulator protein” European Society for Clinical Investigation (ESCI) Budapeszt, Hungary 21.03 – 24.03. 2012

• Mariusz R. Wieckowski „The novel role of uncoupling proteins in example mouse brain” 8th Mitochondria International Physiology Congress, France, 5 – 8 September 2011

• Mariusz R. Wieckowski „Aging and mitochondrial dysfunctions - role of p66Shc lifespan-regulator protein” Mitochondrial Physiology - The Many Functions of the Organism in our Cells, Obergurgl, Austria 27.09 – 01.10.2010

• Mariusz R. Wieckowski „Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders” 16th European Bioenergetics Conference, Warsaw, Poland, 17-22 July 2010,

• Mariusz R. Wieckowski „Oxidative stress connected with the mitochondrial dysfunction – the role of p66Shc and MAO proteins” 44^th Annual Meeting of the Polish Biochemical Society, Łódź, 16-19.09.2009

• Mariusz R. Wieckowski „Age- and mitochondrial pathology-related activation of p66Shc pathway„ IV conference „ Biogerontological Meeting at the Nencki Institute – from development to aging” Warsaw, 17 October 2009

• Mariusz R. Wieckowski „An intimate social triangle – mitochondria, endoplasmic reticulum and plasma membrane. Who keeps company with and why?” The 5th Conference on Mitochondrial Physiology - MiP2007” 14-18 September, Ambleside, The Lake District, England

• Mariusz R. Wieckowski „Development of method and techniques in mitochondrial studies” XII Symposium – Section of Inborn Defects in the Metabolism, Polish Paediatric Society, 15 October 2007, Pułtusk, Poland

• Mariusz R. Wieckowski „The role of p66Shc protein in the oxidative stress” II conference „ Biogerontological Meeting at the Nencki Institute, Warsaw, 14.05.2007

• Mariusz R. Wieckowski „Mitochondria, endoplasmic reticulum and plasma membrane in calcium homeostasis 41^st Annual Meeting of the Polish Biochemical Society, Białystok, 12 - 15 October 2006

• Mariusz R. Wieckowski „Molecular structure of the contact sites formed between mitochondria and ER. Evidence for the PTP role in mitochondrial Ca²⁺ uptake”. MiP2005 4^th Conference on Mitochondrial Physiology 16-20 Sept. 2005 Schröcken, Vorarlberg, Austria,

• Mariusz R. Wieckowski „Mitochondria in cell biology – The story about the most beautiful organelle in the cell” Advances In Pediatrics – Mitochondrial Medicine, 23-24 Nov. 2005, Konstancin Jeziorna, Polska,

• Mariusz R. Wieckowski „How Bax releases cytochrome c from mitochondria? FEBS Advanced Course on "Mitochondria in Cell Life and Death" (2001), Moscow, Russia

• Mariusz R. Wieckowski „Everything you always wanted to know about mitochondria but were afraid to ask” Medical University of Gdańsk and Pomeranian Medical College, Gdańsk, Poland, 05.12.2018

• Mariusz R. Wieckowski „What can we foretell from mitochondrial parameters?“ The Centre of New Technologies, University of Warsaw, 19.04.2018

• Mariusz R. Wieckowski „Mitochondrial diseases-related oxidative stress”, Institute of Physiology Czech Academy of Sciences, 23.10.2017

• Mariusz R. Wieckowski, Lecture on series for the undergraduate medical students, postgraduate students (PhD), researchers and residents in Medicine in the range of Erasmus+, University of Bari Medical School, Bari, Italy, 18.10.2015 – 22.10.2015

• Mariusz R. Wieckowski, Lecture on series „Mitochondrial Medicine” for the I-st year students of Medical University of Gdansk, Facculty of Medicine, Facculty of Dentistry and Facculty of Medicine English Division, 09.05.2014 Gdansk, Poland

• Mariusz R. Wieckowski, Lecture on series „The structure and mitochondrial function. Functioning of the OXPHOS system.” in the frame of the CMKP specialization course in laboratory medical genetics. „Chosen issues from the genetics of metabolic illnesses” 09-13.01.2012 The Children’s Memorial Health Institute, Warsaw, Poland

• Mariusz R. Wieckowski „T The role of p66Shc protein in the cellular response to the oxidative stress” Institut de Pharmacologie Moléculaire et Cellulaire CNRS-UMR 6097, Valbonne, France 08.02.2012

• Mariusz R. Wieckowski „The mystery of MAM fraction - the role of mitochondria associated membranes in physiology and pathology” Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal 17.12.2010

• Mariusz R. Wieckowski „Mitochondria as life and death determinants - their role in the oxygen radical theory of aging" Fachbereich Medizin, JLU Giessen, Germany, 01.02.2007

• Mariusz R. Wieckowski „Two faces of mitochondria – their role in the free radical theory of aging” Medical University of Warsaw, 16.05.2007

• Mariusz R. Wieckowski “Mitochondria, endoplasmic reticulum and plasma membrane in calcium homeostasis. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany 19.10.2006

2. Lectures at the invitation of the institutions:

• Mariusz R. Wieckowski „Everything you always wanted to know about mitochondria but were afraid to ask” Medical University of Gdańsk and Pomeranian Medical College, Gdańsk, Poland, 05.12.2018

• Mariusz R. Wieckowski „What can we foretell from mitochondrial parameters?“ The Centre of New Technologies, University of Warsaw, 19.04.2018

• Mariusz R. Wieckowski „Mitochondrial diseases-related oxidative stress”, Institute of Physiology Czech Academy of Sciences, 23.10.2017

• Mariusz R. Wieckowski, Lecture on series for the undergraduate medical students, postgraduate students (PhD), researchers and residents in Medicine in the range of Erasmus+, University of Bari Medical School, Bari, Italy, 18.10.2015 – 22.10.2015

• Mariusz R. Wieckowski, Lecture on series „Mitochondrial Medicine” for the I-st year students of Medical University of Gdansk, Facculty of Medicine, Facculty of Dentistry and Facculty of Medicine English Division, 09.05.2014 Gdansk, Poland

• Mariusz R. Wieckowski, Lecture on series „The structure and mitochondrial function. Functioning of the OXPHOS system.” in the frame of the CMKP specialization course in laboratory medical genetics. „Chosen issues from the genetics of metabolic illnesses” 09-13.01.2012 The Children’s Memorial Health Institute, Warsaw, Poland

• Mariusz R. Wieckowski „T The role of p66Shc protein in the cellular response to the oxidative stress” Institut de Pharmacologie Moléculaire et Cellulaire CNRS-UMR 6097, Valbonne, France 08.02.2012

• Mariusz R. Wieckowski „The mystery of MAM fraction - the role of mitochondria associated membranes in physiology and pathology” Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal 17.12.2010

• Mariusz R. Wieckowski „Mitochondria as life and death determinants - their role in the oxygen radical theory of aging" Fachbereich Medizin, JLU Giessen, Germany, 01.02.2007

• Mariusz R. Wieckowski „Two faces of mitochondria – their role in the free radical theory of aging” Medical University of Warsaw, 16.05.2007

• Mariusz R. Wieckowski “Mitochondria, endoplasmic reticulum and plasma membrane in calcium homeostasis. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany 19.10.2006

• Organizer of a Workshop “Mitochondria in Health and Disease” during the European Society for Clinical Investigation (ESCI) 55th Annual Scientific Meeting, Virtual Meeting / COVID19 Edition 2021, 9-11 June 2021.

• Organizer of a Workshop “Mitochondrial Biology in Health and Disease/MitoPORTO2019” during the European Society for Clinical Investigation (ESCI) 53rd Annual Scientific Meeting, Coimbra, Portugal, May 22 - 24, 2019

• Organizer of a Workshop “Mitochondria, Aging and Disease” during the European Society for Clinical Investigation (ESCI) 52nd Annual Scientific Meeting, Barcelon, Spain, May 30 - Jun 1st, 2018

• Organizer of a Workshop “Mitochondria Biology and Medicine” during the European Society for Clinical Investigation (ESCI) 51st Annual Scientific Meeting, Genoa, Italy, 17 - 19 May, 2017

• Organizer of a Workshop “Mitochondria, Metabolism and Disease” during the European Society for Clinical Investigation (ESCI) 50th Annual Scientific Meeting, Paris, France, April 27 - 29, 2016

• Organizer of a Workshop “Mitochondrial Research: From Organelle to Patient” during the European Society for Clinical Investigation (ESCI) 49th Annual Scientific Meeting, Cluj-Napoca, Romania, May 27 - 30, 2015

• Organizer of a Workshop “Mitochondrial Disease and Translational Medicine” during the ESCI 2014 -48^th Annual Meeting of the European Society for Clinical Investigation, Utrecht, The Netherlands on April 30 - 03 May, 2014

• Organizer of a Workshop “Mitochondrial physiology: from basic research to the clinic” during the ESCI 2013 -47^th Annual Meeting of the European Society for Clinical Investigation, Albufeira, Portugal on April 17-20, 2013

• Organizer of a Workshop “Mitochondria in Health and Disease” during the ESCI 2012 - 46^th Annual Meeting of the European Society for Clinical Investigation, Budapest, Hungary, March 21-24, 2012

• Member of the National Organizing Committee - 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010

• Member of Institutional Committee for Science Popularization; Nencki Institute of Experimental Biology, Polish Academy of Sciences, from 2018

• Member of the Judging Committee, Doctoral Course in Biomedical Sciences and Biotechnology - University of Ferrara, 2017

• Member of Advisory Doctoral Committee in The Centre of New Technologies, University of Warsaw (regarding PhD of Maria Śladowska from the Laboratory of Mitochondrial Biogenesis) from 2016.

• Member of Advisory Doctoral Committee in the International Institute of Molecular and Cell Biology in Warsaw (regarding PhD of Kinga Gazda from Laboratory of Neurodegeneration) from 2013.

• Member of Institutional Animal House Committee; Nencki Institute of Experimental Biology, Polish Academy of Sciences, from 2013

• Member of Institutional Invention Committee; Nencki Institute of Experimental Biology, Polish Academy of Sciences

• Member of Cátia Diogo Ph.D defense jury. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal, 12 July 2013

• Member of Ana Filipa Roque Branco defense jury. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra/ Portugal, 13 Jun 2013

• Member of the International Scientific Committee of the 9th MiPconference - MiP2013: Comparative Mitochondrial Physiology, Obergurgl, Tyrol, Austria. September 23 – 27, 2013

• Research Collaboration with THERESON company - Investigation of the pulsatory magnetic resonance on mitochondrial metabolism and oxidative stress.

• Collaboration with Dr Irena Eris S.A. company in the range of NCBiR Grant Nr. PBS1/B8/1/2012 „From mitochondria to the innovative cosmetics with protective action” - investigator (participant) results in a Patent (number P.416041), for an invention entitled: “Application of naringenin and a naringenin-containing product and a method of slowing down, counteracting and preventing the process of vitiligo problem”

• Collaboration with PHILIP MORISS (2016 - 2020). From the June 1st 2016 I joined the collaborative project with Philip Morris International (PMI). The project will elucidate selected effects of Reduced-Risk Products (RRP) of PMI on mitochondria.

Lectures for Students & PhD Students:

• Mariusz Wieckowski „What can we foretell from the mitochondrial parameters” Summer School - Life Science Imaging – Workshop on Visualization of Molecules, Interactions and Biological Processes, Warsaw, Poland, June 10-12, 2019,

• Mariusz R. Wieckowski „Western Diet and Non-Alcoholic Fatty Liver Disease” Summer School on Mediterranean Diet - 2nd Edition; Santa Maria Hospital, Terni, Italy 9-15 September, 2018; Terni, Italy

• Mariusz Wieckowski „Visualizing functions of mitochondria” Summer School - Life Science Imaging – Workshop on Visualization of Molecules, Interactions and Biological Processes, Warsaw, Poland, June 5-7, 2017

• Mariusz R. Wieckowski „Mitochondria necessary and dangerous”, IX Liceum Ogólnokształcące im. K. Hoffmanowej, Warsaw, Poland, 19.11.2015

• Mariusz R. Wieckowski, Lecture on series „Mitochondrial Medicine” for the I-st year students of Medical University of Gdansk, Facculty of Medicine, Facculty of Dentistry and Facculty of Medicine English Division, Gdansk, Poland, 09.05.2014

• Mariusz R. Wieckowski, Lecture on series „Energy metabolism in the brain” in the frame of „Basic Neuroscience Course for NeuroPhd Students” for the participants of NeuroPhD program 2011/2012 and 2012/2013. Nencki Institute of Experimental Biology, Warsaw, Poland

• Mariusz R. Wieckowski, Lecture on series „Mitochondrial bioenergetics and oxidative stress” for the students of Adam Mickiewicz University, Poznan, Poland 2007

• Leader of EXP1 part – „Isolation of mitochondria and activity of respiratory chain complexes” of FEBS Advanced Course Frontiers in Molecular Biochemistry of Mitochondria, Nencki Institute of Experimental Biology, Warsaw, Poland, 9-17 June, 2006

• Local co-organizer and lecturer during - One day symposium and practical course „Imaging living cells” organized by University of Ferrara and Telethon Center for Cell Imaging, in the collaboration with Carl Zeiss Company, Jun 18, 2003.

• Editor of Acta Biochimica Polonica

• Editorial Board (Associate Editor) Frontiers in Molecular and Cellular Oncology

• Guest editor - Journal of Signal Transduction

Biochimica et Biophysica Acta, Mitochondrion, Frontiers in Molecular and Cellular Oncology, The International Journal of Biochemistry & Cell Biology, The Journal of Visualized Experiments, Acta Biochimica Polonica, Frontiers in Oncology, Biological Research, Chemico-Biological Interactions, Signal Transduction and Targeted Therapy, Medicinal Research Reviews, Free Radical Biology and Medicine, Cellular Signalling, Biomedicine & Pharmacotherapy, FEBS Letters, Current Drug Targets, Plose One, Ageing Research Reviews etc.

• 23rd Scientific Picnic of Polish Radio and the Copernicus Science Centre was held at the National Stadium on May 31st 2019, supervising of the practical „Mitochondria thematic block” part organized by Nencki Institute of Experimental Biology

• Polish National Children's Fund (KFnRD), lectures and supervising of the practical part organized in Nencki Institute of Experimental Biology, PAS (2013, 2018, 2019)

• 2018 - participation in the TV program (wPolsce.pl) "What is non-alcoholic fatty liver disease and how to treat it"

• Scientific Picnic held Kuligów on August 25th 2018, participation in the practical part organized by Nencki Institute of Experimental Biology

• Lecture “Mitochondria necessary and dangerous”, IX Liceum Ogólnokształcące im. K. Hoffmanowej, Warsaw, Poland, 19.11.2015

• Prof. Paolo Pinton and Prof. Francesco Di Virgilio, Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy

• Prof Paulo Oliviera and Prof. João Ramalho-Santos, Center for Neurociences of Coimbra, University of Coimbra

• Prof. Werner Koopman, Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud Center for Mitochondrial Medicine, Radboudumc, Nijmegen, The Netherlands

• Dr Afshan Malik, Department of Diabetes, School of Life Course, Faculty of Life Sciences and Medicine, King's College London, London, UK

• Prof. Hans Zischka, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, Germany

• Dr hab. Marcin Krawczyk, Saarland University Medical Center, Homburg

• Prof. Piero Portincasa, Department of Biomedical Sciences & Human Oncology University "Aldo Moro" Medical School, Bari, Italy

• Prof. Maciej Pronicki, The Children’s Memorial Health Institute, Warsaw, Poland

• Prof. Michelle L. Matter, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii

• Prof. Agnieszka Dobrzyń, Prof Paweł Dobrzyń and dr hab. Michał Dąbrowski, Nencki Institute of Experimental Biology

• Prof. Grzegorz Węgrzyn, Department of Molecular Biology, University of Gdansk, Gdansk, Poland

• Prof. Krzysztof Zieniewicz and dr Piotr Kalinowski, Department and Clinic of General, Transplant and Liver Surgery, Warsaw Medical University, Warsaw, Poland

• Prof. Michał Woźniak, Department of Medical Chemistry, Medical University of Gdańsk, Gdańsk, Poland

• Dr hab. Wiesław Ziółkowski, Department of Bioenergetics and Nutrition, Gdansk University of Physical Education and Sport, Gdańsk, Poland