Laboratory of Mitochondrial Biology and Metabolism


Grant OPUS-22 LAP from NCN

for Prof. Mariusz Wieckowski

The consortium led by Prof. Mariusz Wieckowski has been granted with OPUS-22 + LAP NCN funding, carried out in international collaboration under the WEAVE Programme for the project: „The role of impaired autophagy and peroxisome function in NAFLD development and their targeted recovery for improved efficacy of n-3 fatty acids”.

The consortium consists of Nencki Institute, Warsaw Medical University and Institute of Physiology of the Czech Academy of Sciences.

Science for Society

a new grant for our Laboratory

On March 23, 2022, by decision of the Minister of Education and Science, the Nencki Institute received a grant under the program "Science for Society" in the area - Scientific Excellence.

Project title: "Effect of omega 3,6,9 polyunsaturated fatty acids on metabolic profile of patients with neurodegeneration associated with iron deposition in the brain". The project leader is Prof. Mariusz R. Więckowski. Total budget is 1.9 million PLN.

The project will be implemented in cooperation with teams led by Prof. Mariusz Wieckowski and Prof. Agnieszka Dobrzyn from the Nencki Institute, and Prof. Iwona Kurkowska-Jastrzebska and dr hab. Marta Skowronska from the Institute of Psychiatry and Neurology in Warsaw. On the social side, the project is supported by the NBIA Poland Association, which unites NBIA patients and their families.

Ines Simoes received

PhD degree

It is with great satisfaction we announce that Ines Simoes (ESR 1) from our laboratory was proclaimed Doctor in Biological Sciences.

The objectives of her PhD, "Effects of Western diet in the development and progression of Non-alcoholic fatty liver disease", were to investigate the importance of mitochondria and peroxisomes in the development of NAFLD.

Congratulations to Dr. Inês Simoes for achieving this incredible milestone, and we wish you the best for the next chapter of your professional life!

Prof. Mariusz Wieckowski, the head of the Laboratory of Mitochondrial Biology and Metabolism at Nencki Institute, has been elected the councilor of the European Society for Clinical Investigation (ESCI) for the time frame of 2022-2024 starting officially in May 2022. The ESCI Council consists of 9-10 European councilors, chosen during and by the Annual Business Meeting of the Society.

The European Society for Clinical Investigation was established in 1967 as a pan-European Society to integrate clinicians and fundamental scientists with a genuine interest in uncovering the mechanisms involved in the pathophysiology of human disease. The objectives of the Society are the advancement of medical practice through science; the cultivation of clinical research by the methods of the natural sciences; the correlation of science with the art of medical practice; the fostering of high standards of ethical practice and investigation and the diffusion of a spirit of fraternity and international cooperation among and through its members. Society provides also a forum for discussion, debate and meeting colleagues in order to advance the science of clinical investigation. The term ‘clinical investigation’ is interpreted widely from bench to bedside including animal studies relevant to humans in health or disease.

Collaboration Agreement WITH NBIA Association Poland signed

Recently we've entered research collaboration with NBIA Association Poland, which unites patients affected by a rare genetic disease characterized by excessive brain iron accumulation (NBIA - neurodegeneration with brain iron accumulation).

The research that will be conducted in our Laboratory (in a close collaboration with the Laboratory of Cell Signalling and Metabolic Disorders headed by Prof. Agnieszka Dobrzyn also from Nencki Institute) will contribute to a better understanding of the pathomechanisms of NBIA disease most likely related to the alterations in lipid metabolism and mitochondrial dysfunction.

The tiger head present in the NBIA Poland Association's logo shows the characteristic -

"Tiger's Eye" visible in the MRI image of children diagnosed with this disease (especially the NBIA-PKAN type).

Towards a better understanding of Leigh Syndrome pathology and intervention published in Brain

A comprehensive review, co-authored by Mariusz R Wieckowski, on how Ndufs4 knockout mouse models have been used to unravel the pathomechanism of Leigh Syndrome has been published in the top-level journal „Brain“. This work is a collaborative effort between the Radboudumc, Wageningen University, The Nencki Institute of Experimental Biology (Warsaw), the Amsterdam UMC and the Universitat Autònoma de Barcelona (Spain).

Want to know more about this paper? Click on the link below for more news.

Collaboration Agreement between Nencki Institute and THERESON S.r.l. signed!

It is a great pleasure to announce that we've entered a research collaboration with THERESON a company focusing on therapeutic magnetic resonance.

Our Laboratory will support THERESON in the effort to expand the spectrum of applications of TMR® Therapeutic Magnetic Resonance, beyond wound care management.

THERESON is an Italian, medical device company, dedicated to the treatment of Vascular pathologies, related to Microcirculation, Orthopedic and Degenerative diseases. Their first medical device DIAPASON®, utilising TMR® Therapeutic Magnetic Resonance in wound care management, was launched to the market in 2017. The company is dedicated to clinical and scientific research and aims to demonstrate the effectiveness of the treatment through rigorously gathered experimental data.